Cryptotanshinone stat3
WebCryptotanshinone rapidly inhibited STAT3 Tyr705 phosphorylation through a JAK2-independent mechanism. Cryptotanshinone selectively inhibits STAT3-activated cell lines … WebJul 25, 2024 · Cryptotanshinone, a natural compound extracted from the root of Salvia miltiorrhiza Bunge, has been identified as a potential STAT3 inhibitor. However, its …
Cryptotanshinone stat3
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WebMay 11, 2024 · Cryptotanshinone suppresses the proliferation and induces the apoptosis of pancreatic cancer cells via the STAT3 signaling pathway. Mol Med Rep 2015; 12 : 7782–7788. Article CAS Google Scholar WebMay 11, 2024 · Cryptotanshinone inhibits human glioma cell proliferation in vitro and in vivo through SHP-2-dependent inhibition of STAT3 activation Download PDF Your article has downloaded
WebCostunolide, an active sesquiterpene lactone, is derived from several medicinal plants, such as Saussurea lappa Decne and Laurus nobilis L. Jin et al. showed that costunolide inhibited osteosarcoma growth and metastasis by suppressing STAT3 activity . Cryptotanshinone, an active quinoid diterpene, can be isolated from Salvia miltiorrhiza Bunge ... WebMay 27, 2024 · EPT3M1-STAT3 cells (grown on coverslips) were treated with DMSO, 20 µM 323–1 or 323–2, 100 µM S3I-201, or 5 µM cryptotanshinone for 24 h. Cells were fixed with 4% paraformaldehyde, …
WebOct 27, 2024 · Cryptotanshinone is a bioactive component present in the dried roots of Salviamiltiorrhiza Bunge (Danshen), and was reported, in the year 2009, as a STAT3 … WebCryptotanshinone induces cell cycle arrest and apoptosis through the JAK2/STAT3 and PI3K/Akt/NFkB pathways in cholangiocarcinoma cells. Background: Cholangiocarcinoma …
WebApr 26, 2015 · Cryptotanshinone suppresses Stat3 phosphorylation in colorectal cancer cells. HCT116 and SW480 cells were seeded as 2 × 10 4 in 100-mm plates and after 24 h were treated with 0.1 % DMSO, 5, 10, 25, or 50 µmol/L CPT. After 24 h of treatment, extracts were analyzed by Western blotting analysis. a, c Total and phosphorylated Stat3.
WebJan 14, 2024 · A positive combination effect between cryptotanshinone and senkyunolide I, two representative compounds from the two GXNT herbs, was identified in the regulation of thrombogenesis, which possibly functions through mediating oxidative stress, platelet activation and coagulation cascade. incydent itWebCryptotanshinone Inhibits STAT3, but Not STAT5, Signaling in K562 Cells Parallel assays were carried out in cryptotanshinone-treated K562 cells. Different from tanshinone IIA, cryptotanshinone reduced the phosphorylation level of STAT3, but not STAT5, in a dose- and time-dependent manner (Figure 3 (a) ). incydent ilfracombeWebDec 31, 2008 · Cryptotanshinone binds to STAT3 monomer and inhibits the dimerization of STAT3. To visualize cryptotanshinone inhibition of STAT3 localization in intact cells, … include filtered items in totals greyed outWebanticancer therapy, that promotes the binding of signal transducer and activator of transcription 3 (STAT3) to Cryptotanshinone has been investigated. This binding tremendously reduces both the cellular production of STAT3, and the availability of the STAT3 dimers that drive production of various cellular oxygen and electron sources [11]. include firstWebAug 9, 2024 · Cryptotanshinone (CT) effectively inhibited glucose uptake and lactate production in ovarian cancer cells. CT exerted its anti‐tumor effect by targeting STAT3/SIRT3/HIF‐1α signaling pathway in vitro and in vivo. CT may be developed as a chemotherapeutic agent to treat ovarian cancer. Go to: 1. INTRODUCTION include flagWebOct 27, 2024 · A new synthetic derivative of cryptotanshinone KYZ3 as STAT3 inhibitor for triple-negative breast cancer therapy Silencing STAT3 is confirmed as a promising therapeutic strategy for triple-negative breast cancer (TNBC) therapy to address the issue of its poor prognosis. incydent plWebOct 27, 2024 · Two STAT3 overactivated human TNBC cell lines (MDA-MB-231 and MDA-MB-468) were employed to test the activity of designed compounds with cryptotanshinone and BP-1-102 as the positive control by 3 ... incydent w ghostland