Cisplatin alkylating agent
WebDec 19, 2011 · Alkylating agents Cause DNA cross-links and prevent cell replication ... The platinum-based chemotherapy agents cisplatin, carboplatin, and oxaliplatin, used to treat a huge number of cancers including the lung, upper and lower GI, ovarian, and germ cell tumours, are a common cause of renal tubular and glomerular damage, which can be … WebCisplatin is a platinum-based agent whose nephrotoxicity is thought related to the chloride in the cis position. Cisplatin gains entry into tubular cells via uptake by the OCT-2 …
Cisplatin alkylating agent
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WebSep 15, 2024 · Cisplatin is the prototype platinum coordination complex classified as an alkylating agent and used intravenously in the treatment of several forms of … WebCytostatic antibiotics of the anthracycline class are the best known of the chemotherapeutic agents that cause cardiotoxicity. Alkylating agents such as cyclophosphamide, ifosfamide, cisplatin, carmustine, busulfan, chlormethine and mitomycin have also been associated with cardiotoxicity.
WebNov 1, 2004 · The platinum coordination complexes (cisplatin, carboplatin, oxaliplatin) and most alkylating agents form strong electrophilic intermediates that act via nucleophilic substitution reactions to form inter- and intrastrand DNA crosslinks. WebCarboplatin, cisplatin, oxaliplatin, cyclophosphamide, and melphalan are exemplary alkylating agents that work by causing DNA damage. Such agents work by adding an alkyl group to the guanine base of the DNA molecule, preventing the strands of the double helix from linking as they should.
WebAlkylating agents Alkylating agents keep the cell from reproducing (making copies of itself) by damaging its DNA. These drugs work in all phases of the cell cycle and are used to treat many different cancers, including cancers of the lung, breast, and ovary as well as leukemia, lymphoma, Hodgkin disease, multiple myeloma, and sarcoma. WebMar 26, 2024 · For platinum alkylating-like drugs, in contrast to the parent compound cisplatin, the newer-generation drug carboplatin is reported to have reduced toxicity in …
WebAlkylating agents (AAs), are a group of chemo drugs generally divided into six classes; triazenes, nitrogen mustards, nitrosoureas, ethylenimine and methylenamine derivatives, alkyl sulfonates, and platinum-containing antineoplastic agents, which are commonly used, alone or in combination, in high-dose chemotherapy regimens to treat certain types of …
WebThe introduction of this agent slightly bends the DNA duplex to accommodate for the agent's presence within the helix. These agents are often introduced as a pharmaceutical and are used in cytotoxic chemotherapy. Cisplatin (cis-diamminedichloroplatinum(II)) and its derivatives mostly act on adjacent guanines at their N 7 positions. can i use heavy gesso for raised stencilsWebAlkylating agent combined with the lanthanide compound in the absence of conjugated diene monomer or in the presence of a small amount of conjugated diene monomer at a temperature in the range of the approximately 20º to about 80ºC. ... Although cisplatin is frequently designated as an alkylating agent, ... can i use he detergent in a non he washerWebSep 6, 2024 · Chemotherapeutic agents, also referred to as antineoplastic agents, are used to directly or indirectly inhibit the uncontrolled growth and proliferation of cancer cells. They are classified according to their mechanism of action and include. alkylating agents. , antimetabolites. , topoisomerase inhibitors. , antibiotics, mitotic inhibitors, and. fivepointsvidsWebThe term “alkylating agent” has been defined and a detailed discussion made of the mechanisms (Sn1 and Sn2) by which they interact with nucleophilic centers. The various … five points wedding chapelWebSep 15, 2024 · Mabs, the main cause of type 2 damage, are widely used in the management of many types of cancer. Chemotherapy agents that can cause reversible cardiotoxicity are trastuzumab, bevacizumab, lapatinib, and sunitinib. These agents also may cause hypertension. A decrease in vascular endothelial growth factor (VEGF) results in a … can i use heat tape on pvcWebCisplatin is another alkylating agent that is used to treat lung cancer, as well as other types of cancer including testicular, ovarian, bladder, head and neck, esophageal, breast, cervical, stomach, and prostate cancers. Cisplatin is also used in the treatment of lymphomas, neuroblastoma, sarcomas, multiple myeloma, melanoma, and mesothelioma. five points windows and doorsWebCisplatin is classified as an alkylating agent. Alkylating agents are most active in the resting phase of the cell. These drugs are cell cycle non-specific. Note: We strongly … can i use hello in formal email